筛选天然药物-GriffithResearchOnline-GriffithUniversity.PDFVIP

筛选天然药物 天然产物挑战现有科学规则并增加筛选命中率 Screening nature Natural products challenge scientific rules and increase screening hit rates 索生物学作用机制和小分子物质药理学活性的范例已 he paradigm for probing biological processes and small 经在过去的10到15年之间发生了重大的改变。以往采 molecules for pharmacological activity has changed 探用动物模型评价几十种或几百种化合物的方法，已经 Tsignificantly over the past 10 to 15 years. The previous 被针对特定靶点或细胞的模型，来筛选成千乃至上百万种化合物的 protocol in which tens or hundreds of compounds were tested 方法所替代。美国大型制药企业, 生物技术公司和公共基金资助的 in animal models has been replaced by one where thousands 国立卫生研究院都在高通量筛选技术（HTS）上投入大量资金用于 to millions of compounds are routinely screened against a 鉴定与蛋白质、受体、脱氧核糖核酸（DNA）和核糖核酸（RNA）相 specific target or cellular assay. Big pharmaceutical companies, 互作用的分子。 biotechnology companies and publicly funded national institutes 36 PharmaTechnology • 医药技术 药物研发 Drug discovery of health in the US have all made significant investments in high throughput screening (HTS) to identify molecules that interact with proteins, receptors, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).