3-硝基丙酸中毒小鼠恢复运动功能后呈现抑郁样症状.pdfVIP

维普资讯 NeurosciBull Augustl，2008，24(4)：225—230．http：／／www．neurosci．Cil D0I：l01007／sl2264—008—0304—2 225 · OriginalArticle’ Depressive-likebehaviorinmicerecentlyrecoveredfrom motordisorders ^ ‘ · · · ’ · · - · ‘ atter -nitropropionicacidintoxlcarlon Xiao—M inLI，Bing—GenZHU。，，ShaMA。，WeiZHOU ，ZhengWEI。，Yu—XiangZHENG ，Xu—DongZHAO ，Rong—ShenZHU DepartmentofPh3’siology,DepartmentofPsychiat~,TongjiUniversitySchoolofMedicine，Shanghai200092，China Abstract：Objective Striatummaybeinvolvedindepressivedisordersaccordingtotheneuroimaginganalysisandclinical data．However，noanimalmodelatpresentsupportedthepossibleroleofstriatum inthepathogenesisofdepression．Inthe presentstudy，wehaveinvestigatedthedepressive—likebehaviorinmicerecentlyintoxicatedwith3-nitropropionicacid(3一 NP)，awidelyknowntoxinthatselectivelydamagesthestriatum inthebrain．Methods Mousemodelwasmadewithsubacute systemic3-NPtreatment，andthedepressive—likebehaviorwasmeasuredusingthedurationofimmobilityduringforced swimmingtest(FST)．Results Whenthemiceatday15post—intoxicationjusttotallyrecoveredrfommotordeficits，the durationofimmobilityinFSTwassignificantlylongerthanthatincontrols．Thedepressive—likebehaviorwasnotduetothe fatigueorgener~ sicknessfollowing3-NPintoxicationna dcouldbereversedbythena tidepressna t，desipraminehydrochloride． IntwosuccessiveFSTin24hinterval，thedepressive—likebehaviorcouldbeobservedagaininsubsequentFST(atday16 post—intoxication)．andthemicepresentedanormal“learnedhelplessness”．Conclusion Anoveldepressionanimalmodel couldbeestablishedinmiceduringtheinitialperiodofrecoveryfrom 3-NPintoxication．Thedepression—likebehaviormigh