《Dihydro Artemisinin》.pdfVIP

Dihydro Artemisinin sc-211332 Material Safety Data Sheet Hazard Alert Code EXTREME HIGH MODERATE LOW Key: Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Dihydro Artemisinin STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY 1 HEALTH HAZARD INSTABILITY 0 0 SUPPLIER Company: Santa Cruz Biotechnology, Inc. Address: 2145 Delaware Ave Santa Cruz, CA 95060 Telephone: 800.457.3801 or 831.457.3800 Emergency Tel: CHEMWATCH: From within the US and Canada: 877-715-9305 Emergency Tel: From outside the US and Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 PRODUCT USE A fast acting blood schizontocide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria. Inhibits PfATP6 (Plasmodium calcium ATPase) Main metabolite of artemisinin, arteether, artemether, artesumate SYNONYMS C15-H24-O5, dihydroqinghaosu, schistosomicide, antiameobic, antimalarial, artemisinin, PfATP6 inhibitor Section 2 - HAZARDS IDENTIFICATION CANADIAN WHMIS SYMBOLS None EMERGENCY OVERVIEW RISK POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ■ Accidental ingestion of the material may be damaging to the health of the individual. ■ At sufficiently high doses the material may be neurotoxic(i.e. poisonous to the nervous system). ■ The sesquiterpene lactones (SLs) are highly i