具有生理活性的天然螺缩酮化合物研究进展有机化学.pdfVIP

2009 年第 29 卷 有 机 化 学 Vol. 29, 2009 第 10 期, 1508～1521 Chinese Journal of Organic Chemistry No. 10, 1508～1521 ·综述与进展· 具有生理活性的天然螺缩酮化合物研究进展 魏荣宝* 李文丽 刘 博 梁 娅 (天津理工大学化学化工学院 天津 300191) 摘要 螺缩酮类化合物广泛存在于自然界中, 它们表现出的很好的生理活性已引起各国科学家的兴趣. 对近年来天然 存在的螺缩酮化合物的研究进展进行了总结, 描述了这类化合物的结构特征, 展望了在医药、农药等方面的潜在发展 前景. 关键词 螺缩酮化合物; 生理活性; 异头效应; 手性轴 Progress in the Studies on Biological Activities of Natural Spiroketal Compounds Wei, Rongbao* Li, Wenli Liu, Bo Liang, Ya (College of Chemistry Chemical Engineering, Tianjin University of Technology, Tianjin 300191) Abstract Spiroketal compounds enjoy widespread occurrence as substructures of naturally occurring sub- stances from many sources, including insects, microbes, plants and marine organisms. The increasing phar- macological importance of such compounds containing spiroketal assemblies has triggered intense interest in both their synthesis and chemical reactivity. The recent progress in the studies on the spiroketal compounds is reviewed. Their structural features are described in detail and the synthetic methods of some spiro organic compounds are also provided. At last the prospects of this kind of spiro compounds in medicine and pesti- cide are made. Keywords spiroketal compound; physiological activity; anomeric effect; chiral axis 螺缩酮类化合物广泛存在于自然界中, 它们表现出 的链霉菌中提取出来的(Scheme 1). 的生理活性已引起各国科学家的极大兴趣. 其中昆虫信 它具有抗核盘霉(Sclerotinia sclerotiorum) 的作用, 息素(insect pheromones)、微生物(microbes)、真菌(fungi)、 可阻止丝氨酸-