含邻氟苯基的1,2,4-三唑类衍生物的合成及杀菌活性研究有机化学.pdfVIP

DOI: 10.6023/cjoc201207020 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 含邻氟苯基的1,2,4-三唑类衍生物的合成及杀菌活性研究 童建颖a 石延霞c 刘幸海*,b 孙娜波a,b 李宝聚*,c a ( 浙江树人大学生物与环境学院 杭州 310015) (b 浙江工业大学化学工程与材料学院 杭州 310014) (c 中国农业科学院蔬菜花卉研究所 北京 100014) 摘要 以邻氟苯甲酸、水合肼、苯基异硫氰酸酯等为原料, 通过多步反应制备了一系列邻氟苯基联三唑类衍生物, 并 考察了微波辐射对反应的影响. 产物结构均经过 1H NMR, MS 和元素分析确证; 对所有化合物进行了活体杀菌活性测 试, 结果表明大部分化合物对黄瓜褐斑病、黄瓜核菌病、黄瓜霜霉病、黄瓜细菌性角斑病均具有较好的防效. 关键词 1,2,4-三唑; 合成; 杀菌活性; 邻氟苯甲酸 Synthesis and Fungicidal Activity of 1,2,4-Triazole Derivatives Containing 2-Fluorophenyl Moiety Tong, Jianyinga Shi, Yanxiac Liu, Xinghai*,b Sun, Naboa,b Li, Baoju*,c (a College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015) (b College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014) c ( Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100014) Abstract A series of novel 1,2,4-triazole derivatives were synthesized from o-fluorobenzoic acid, hydrazine hydrate, phenyl isothiocyanate by multi-step reactions. Their structures were characterized by 1H NMR, MS and elemental analyses. The target compounds were evaluated for their fungicidal activities against Corynespora cassiicola, Pseudomonas syringae pv. Lachry- mans, Pseudoperonospora cubensis and Sclerotinia sclerotiorum in vivo, and the results indicated that som