新型脱氢枞胺衍生物的合成及其抗自由基活性有机化学.pdfVIP

DOI: 10.6023/cjoc201211020 研究论文 有机化学 Chinese Journal of Organic Chemistry ARTICLE 新型脱氢枞胺衍生物的合成及其抗自由基活性 陆 洲 刘超祥 余 星 林中祥* (南京林业大学化学工程学院 南京 210037) 摘要 通过不同的方法在脱氢枞胺中引入酰腙、没食子酸、肟、异烟基等对清除自由基有效果的基团, 设计合成了几 种新型的脱氢枞胺衍生物. 利用 1H NMR, 13C NMR, IR 和 HRMS 对所有合成的化合物进行了结构表征. 测试了所合成 的化合物对清除超氧阴离子( O－)和二苯代苦味酰基自由基(DPPH•) 的活性, 其中 N-(3,4,5-三羟基苯甲酰基)-脱氢枞胺 2 (6)对 － 3 O2 的抑制率达到 38.18%, 是常用抗氧化药物 Vc (18.35%) 的两倍以上; 对(DPPH•)的半数抑制浓度为 0.002 ×10 3 mg/L, 远优于 Vc (0.236 ×10 mg/L). 关键词 脱氢枞胺; 抗自由基; 酰腙; 没食子酸 Synthesis and Anti-free Radical Activities of Several Novel Derivatives of Dehydroabietylamine Lu, Zhou Liu, Chaoxiang Yu, Xing Lin, Zhongxiang* (College of Chemical Engineering Nanjing Forestry University, Nanjing 210037) Abstract A series of novel derivatives of dehydroabietylamine were synthesized by introducing some groups with good free radical scavenging activities into the dehydroabietylamine, such as hydrazone, gallic acid, oxime and isoniazid. Structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, MS and HRMS techniques. All the compounds were tested the ability on scavenging superoxide anion radical ( O－) and 1,1-dipheny-2-picrylhydrazyl (DPPH•). The results 2 indicate that the inhibitory rate of O2－ by (6)