新型苯并咪唑环蕃的合成与晶体结构研究有机化学.pdfVIP

DOI: 10.6023/cjoc201209043 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 新型苯并咪唑环蕃的合成与晶体结构研究 * 侯晓萌 徐林飞 唐雪松 宋 阳 白银娟 (合成与天然功能分子化学教育部重点实验室 西北大学化学与材料科学学院 西安 710069) 摘要 以二溴甲基苯(o, m, p)为原料, 分别与 2-巯基苯并咪唑环化合成相应的含硫苯并咪唑环蕃, 实验发现二溴甲基取 代位置对反应结果有很大影响, o-位取代很易生成[1:1]型环化产物, p -位取代则主要得到链状产物, m-位取代环化产物 1 较复杂, 但以[2:2]型环化产物为主. 产物结构通过 H NMR, IR, HRMS 进行了表征, 并得到了 1-3a 的X 射线单晶衍射 晶体结构, 对其晶体结构进行了分析. 关键词 苯并咪唑环蕃; 合成; 表征; 晶体结构 Synthesis and Crystal Structure of Novel Benzimidazole Cyclophanes Hou, Xiaomeng Xu, Linfei Tang, Xuesong Song, Yang Bai, Yinjuan* (Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry Materials Science, Northwest University, Xian 710069) Abstract The novel sulfur-containing benzimidazole cyclophanes were synthesized from bis(bromomethyl)benzene (o, m, p ) and 2-benzimidazolinthion, respectively. The reaction showed that bromomethyl positions effected the aim compounds very much. It was easy for o-substituted to generate the [1:1] type cyclization product. p -Substituted obtained chain product, and m-substituted benzene pruduced the [2:2] type cyclization compound as main product. The lead compounds were characterized by 1H NMR, IR, HRMS, and the structure of 1-3a was determined by X-ray diffraction method. Keywords benzimidazole cyclophane; synthesis; charact