铜-手性氮杂环卡宾化合物催化的不对称1,4-共轭加成反应有机化学.pdfVIP

2011 年第 31 卷 有 机 化 学 Vol. 31, 2011 第 4 期, 443～452 Chinese Journal of Organic Chemistry No. 4, 443～452 ·综述与进展· 铜-手性氮杂环卡宾化合物催化的不对称 1,4-共轭加成反应 a a *,a,b a 于艳飞 单凤军 李争宁 姜 岚 (a 大连大学环境与化学工程学院 大连 116622) (b 辽宁省生物有机化学重点实验室 大连 116622) 摘要 近年来, 利用金属-手性氮杂环卡宾(NHC)化合物进行不对称催化反应已取得了快速发展. 相关报道越来越多, 一些反应已获得良好的对映异构体选择性, 这显示出金属-NHC 化合物在催化合成手性化合物中的潜在用途. 按 NHC 为单齿、双齿配体总结了金属-手性 NHC 化合物对 α,β -不饱和酮的共轭加成反应的不对称催化, 以期对发现高立体选 择性金属-NHC 催化剂提供一些启发. 关键词 金属-NHC 化合物; 铜; 不对称催化; 共轭加成 Asymmetric 1,4-Conjugate Addition Reactions Catalyzed by Cu-Chiral N-Heterocyclic Carbene Complexes Yu, Yanfeia Shan, Fengjuna Li, Zhengning*,a,b Jiang, Lana a ( College of Environmental and Chemical Engineering, Dalian University, Dalian 116622) (b Liaoning Key Laboratory of Bioorganic Chemistry, Dalian 116622) Abstract Rapid advance has been achieved in the asymmetric catalysis using metal-chiral N-heterocyclic carbene (NHC) complexes as the catalysts in recent years. Increasing number of reports in this field and high enantioselectivities obtained under the catalysis of metal-NHC complexes have demonstrated the potential importance of metal-chiral NHC complexes in the catalytic, asymmetric synthesis of chiral compounds. Metal-chiral NHC complexes-catalyzed conjugate addition of α,β -unsaturated carbonyl compounds is