Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts.pdfVIP

Hindawi Publishing Corporation Malaria Research and Treatment Volume 2012, Article ID 727032, 8 pages doi:10.1155/2012/727032 Research Article Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts Hossein Nahrevanian,1 Bayram Sheykhkanlooye Milan,2 Masoud Kazemi,3 Reza Hajhosseini,2 Soudeh Soleymani Mashhadi,1 and Shahab Nahrevanian1, 4 1 Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran 2 Division of Biochemistry, Department of Basic Sciences Agriculture, Payame Nour University, Tehran, Iran 3 Department of Applied Chemistry, Islamic Azad University, Qom Branch, Qom, Iran 4 Department of Molecular Biology, Umea University, Umea, Sweden ˚ ˚ Correspondence should be addressed to Hossein Nahrevanian, mobcghn@ Received 6 December 2011; Revised 31 December 2011; Accepted 5 January 2012 Academic Editor: Polrat Wilairatana Copyright © 2012 Hossein Nahrevanian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The aim of this study is pharmacochemistry of Iranian flora Artemisia sieberi and its antimalarial effects on Plasmodium berghei in vivo. This is the first application of A. sieberi for treatment of murine malaria. A. sieberi were collected at flowering stage from the Khorassan and Semnan provinces of Iran; the aerial parts were air-dried at room temperature and then powdered. The powder was macerated in methanol, filtered with Bokhner hopper and solvent was separated in rotary evaporator. Total herbal extract was