EB病毒、p53、bcl-2、c-myc和Rb蛋白在非霍奇金淋巴瘤发病及病情演化中的价值.pdf

．1064． 中国肿瘤临床 2006年第33卷第18期 在非霍奇金淋巴瘤发病及病情演化中的价值 摘要 myc蛋白与NHL病情恶化成正相关关系。Rb蛋白则为负相关关系。 关键词 非霍奇金淋巴瘤 EBV bcl一2Rb p53 c—myc 中图分类号：R730．45文献标识码：A 文章编号：1000—8179(2006)18—1064—04 TheValuesofEB andRb bcl-2，c-mycproteins Virus，p53， inOnsetand of DevelopmentNon-HodgkinsLymphomas LiuHua Wei Chui-zhietal Wang Zheng Medical Provincial3 Deptof Oncology,HainanPeopleHospital，Haikou valuesoftheEB and Abstract Rb Objective：Toprobe virus(EBV)，mutantp53，bel-2，c-myc inonsetand virus，mutantp53， proteins developmentnon—Hodgkin7Slymphomas(NHL)．Methods：EB andRb in from140caseswithNHLweredetectedimmunohisto— bcl-2，e-myeproteinssamples using from51 caseswithreactive wereusedasCOll— chemistry(S-Pmethod)．Meanwhile，samples lymphatitis tothecontrol EBV，mutant were tr01．Results：Comparedgroup，the p53，bcl一2，C--mycup-regulated andRbwas NHL wasirrelevanttomutant down—regulated(P0．05)ingroup．EBV p53，bcl-2c-myc andRbin oftheNHL themutantandbcl一2were differ— development fP0．05)．Both p53 significantly indifferent andRbwere entlyexpressed grade-NHL(P0．05)．EBV，mutantp53，bcl-2c—myc signifi— indifferent