Hodgkins Disease in Patients with HIV Infection.pdfVIP

Hindawi Publishing Corporation Advances in Hematology Volume 2011, Article ID 402682, 7 pages doi:10.1155/2011/402682 Review Article Hodgkin’s Disease in Patients with HIV Infection Michele Spina,1 Antonino Carbone,2 Annunziata Gloghini,3 Diego Serraino,4 Massimiliano Berretta,1 and Umberto Tirelli1 1 Division of Medical Oncology A, National Cancer Institute, via Franco Gallini 2, 33081 Aviano (PN), Italy 2 Division of Pathology, National Cancer Institute, via Franco Gallini 2, 33081 Aviano (PN), Italy 3 Department of Pathology, and Laboratory Medicine, Fondazione IRCCS, National Cancer Institute, via Giacomo Venezian 1, 20133 Milan, Italy 4 Unit of Epidemiology and Biostatistics, National Cancer Institute, via Franco Gallini 2, 33081 Aviano (PN), Italy Correspondence should be addressed to Michele Spina, mspina@cro.it Received 29 June 2010; Revised 17 August 2010; Accepted 26 August 2010 Academic Editor: Thomas G. Gross Copyright © 2011 Michele Spina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hodgkin lymphoma (HL) represents one of the most common non-AIDS-defining cancers with an increasing incidence overtime. Clinically, patients present advanced stages of disease with extranodal involvement in the majority of cases. In the last years, significant improvements in the treatment of patients with HL and HIV infection have been achieved. In the lack of randomized trials, several phase II studies have showed that in the era of highly active antiretroviral therapy (HAART) the same regimens employed in HIV-negative patients with HL can be used in HIV setting with similar results. Moreover