Hodgkins Lymphomas A Tumor Recognized by Its Microenvironment.pdfVIP

Hindawi Publishing Corporation Advances in Hematology Volume 2011, Article ID 142395, 6 pages doi:10.1155/2011/142395 Review Article Hodgkin’s Lymphomas: A Tumor Recognized by Its Microenvironment S. Montes-Moreno Lymphoma Group, Spanish National Cancer Centre (CNIO), E-28029, Madrid, Spain Correspondence should be addressed to S. Montes-Moreno, smontes@cnio.es Received 30 June 2010; Accepted 3 October 2010 Academic Editor: Meral Beksac Copyright © 2011 S. Montes-Moreno. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Thomas Hodgkin’s and Samuel Wilks first recognized Hodgkin disease in the first half of the 19th century. Initially described as lymphogranulomatosis, it was later recognized to be a lymphoid neoplasm derived from B cells and was classified on the basis of its histopathological features. Hodgkin lymphomas are now regarded as encompassing two clearly defined entities according to the WHO classification: nodular lymphocyte-predominant Hodgkin Lymphoma (NLPHL) and classical Hodgkin Lymphoma (CHL). This paper focuses on the current knowledge about the biological features that characterize both NLPHL and CHL, highlighting those relevant to correct pathological diagnosis and those that might be associated with patient outcome. 1. Introduction diagnosis and those that might be associated with patient outcome. Hodgkin’s disease was first recognized in the first half of the 19th century by Hodgkin [1] and Wilks [2, 3]. Initially described as lymphogranulomatosis, it wa