Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels.pdfVIP

SAGE-Hindawi Access to Research Journal of Thyroid Research Volume 2011, Article ID 194721, 5 pages doi:10.4061/2011/194721 Research Article Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels Chih-Hsun Chu,1, 2 Hing-Chung Lam,1, 3 Jenn-Kuen Lee,1, 3 Chih-Chen Lu,1 Chun-Chin Sun,1 Mei-Chun Wang,1 and Ming-Ju Chuang1 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan 2 Department of Rehabilitation Technology, TzuHui Institute of Technology, 367, San Min Road, Nanchou, Pingtung 926, Taiwan 3 School of Medicine, National Yang-Ming University, 155, Sec. 2, Li-Nong Street, Pei-Tou, Taipei 112, Taiwan Correspondence should be addressed to Chih-Hsun Chu, chchu@.tw Received 8 September 2010; Revised 30 November 2010; Accepted 19 December 2010 Academic Editor: Gabriela Brenta Copyright © 2011 Chih-Hsun Chu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To evaluate the relationship between circulating adiponectin and insulin sensitivity in patients with hyperthyroid Graves’ disease, we studied 19 adult patients with this disease and 19 age- and sex-matched euthyroid controls. All hyperthyroid patients were treated with antithyroid drugs and were re-evaluated after thyroid function normalized. Before antithyroid treatment, the adiponectin plasma concentrations were not different comparing with those in control group. The adiponectin levels remained unchanged after treatment. The homeostasis model assessment of insulin resistance (H