In Silico Analysis for Transcription Factors With Binuclear Cluster DNA-Binding Domains in Candida albicans.pdfVIP

Comparative and Functional Genomics Comp Funct Genom 2005; 6: 345–356. Published online 21 October 2005 in Wiley InterScience (). DOI: 10.1002/cfg.492 Research Article In silico analysis for transcription factors with Zn(II)2C6 binuclear cluster DNA-binding domains in Candida albicans 1 2 2 ´ 1 2 Sergi Maicas , Inmaculada Moreno , Almudena Nieto , Micaela Gomez , Rafael Sentandreu ´ 2 and Eulogio Valent ın * 1 ´ ´ ` Departamento de Bioquımica y Biologıa Molecular, Universitat de Valencia, 46100-Burjassot, Valencia, Spain 2 ´ ´ ` Departamento de Microbiologıa y Ecologıa, Universitat de Valencia, 46100-Burjassot, Valencia, Spain *Correspondence to: Abstract ´ Eulogio Valentın, Departamento ´ ´ A total of 6047 open reading frames in the Candida albicans genome were screened for de Microbiologıa y Ecologıa, Zn(II) C -type zinc cluster proteins (or binuclear cluster proteins) involved in DNA Facultad de Farmacia, Universitat 2 6 ` ´ recognition. These fungal proteins are transcription regulators of genes involved in a de Valencia, Avda. Vicent Andres ´ wide range of cellular processes, including metabolism of different compounds such i Estelles s/n, 46100-Burjassot, Valencia, Spain. as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell E-mail: Eulogio.Valentin@uv.es wall architecture, etc. The selection criteria used in the sequence analysis were the