Incidental Cutaneous Reaction Patterns Epidermolytic Hyperkeratosis, Acantholytic Dyskeratosis, and Hailey-Hailey-Like Acantholysis A Potential Marker of Premalignant Skin Change.pdfVIP

Hindawi Publishing Corporation Journal of Skin Cancer Volume 2011, Article ID 645743, 5 pages doi:10.1155/2011/645743 Research Article Incidental Cutaneous Reaction Patterns: Epidermolytic Hyperkeratosis, Acantholytic Dyskeratosis, and Hailey-Hailey-Like Acantholysis: A Potential Marker of Premalignant Skin Change Erich M. Gaertner SaraPath Diagnostics, 2001 Webber Street, Sarasota, FL 34239, USA Correspondence should be addressed to Erich M. Gaertner, dermpathdoc@ Received 8 December 2010; Accepted 28 January 2011 Academic Editor: M. Lebwohl Copyright © 2011 Erich M. Gaertner. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Focal acantholytic dyskeratosis (FAD), epidermolytic hyperkeratosis (EHK), and Hailey-Hailey-like acantholysis (HH) represent unique histology reaction patterns, which can be associated with defined phenotypic and genotypic alterations. Incidental microscopic foci demonstrating these patterns have been identified in skin and mucosal specimens in association with a gamut of disease processes. These changes, when secondary, are of unclear etiology and significance. The following study further analyzes the incidence and association of these histologic patterns in a routine pathology/dermatopathology practice. 1. Introduction focal acantholytic dyskeratosis (FAD). Subsequently, 500 consecutive skin specimens were reviewed by the author A variety of incidental microscopic cutaneous changes have (8/08-9/08) at a different institution to evaluate for inci