Treatment results and prognostic analysis of 1093 primary nasopharyngeal carcinoma: the experience of a single institution of Guangzhou in the beginning of the 21st century.pdfVIP
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维普资讯
nosticanalysisof1093
primarynasopharyngealcarcinoma:theexperience
ofasingleinstitutionofGuangzhouinthebeginning
ofthe21stcentury
XiaoqingLiu,W eiLuo,MengzhongLiu,LingYe,YingSun,YunfeiXia
DepartmentofRadiationOncology,CancerCenter,SunYat—senUniversity,Guangzhou510060,China
Received:7November2007/Revised:13December2007/Accepted:20January2008
Abstract Objective:Toanalyzelhelreatmenlresultsofprimarynasopharyngealcarcinoma(NPC)lreatedinourinstitu—
liOninlhebeginningoflhe21slcenturytoidentifykeyfailuresandIateeffedsf0rrefiningfuturelreatments.Methods:1093
patientswithprimaryNPClreatedduringDecember2001andJune2003wereretrospectivelyanalyzed.Thedistributionac—
cordingtotheAJCC/UICC(2002edition)stagingsystemwasstage 5.8%,stageII40.2%,stage…32.7%andstageIVa—b
21.3%.FourdifierenlERTtechniqueswereused:fluoroscopysimulationconventionaIradiotherapy(CR)in74.3%ofpatients,
computertomographysimulationconventionaIradiotheraIPY(CT-simCR)14.2%,lhreed·imensionaIconformaIradiotherapy
(3D.CRT)6.3%,intensitymodulatedradiotherapy(IMRT)5.2%.Inlhewholeseries,46.7%ofpatientshadadditionaIlreat—
menlwithchemotherapy.Results:The4-yearIocaIfailure-freerate(LFFR),nodaIfailure-freerate,distanlmetastasis-free
rate,progression-freesuwivaIandoveralIsurvivaI(OS)was89.6%,96.1%,85.9%,73.0%and82.4%,respectively.Thesatge
waslhemoslimportantprognosticfactor.The4-yearOSandLFFRofpatientslreatedbyCR,CT-simCR,3D—CRTandIMRT
was80.2%。89.8%,89.8%,92.4%and87.7%,96.4%,91.0%,96.5%,respectively.Themorbidityanddegreeofxerostomia
andlrismuswereIowerinlhepatientslreatedby3D.CRTandIMRTlhanbyCRandCT-simCR.Conclusion:Treatmenl
resultsofprimaryNPCinourinstitutionhavebeensubst
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