原创力文档Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2.PDFVIP
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Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2.PDF
Ligand-dependent interaction of the
glucocorticoid receptor with p53
enhances their degradation by Hdm2
Sagar Sengupta1 and Bohdan Wasylyk2
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 163, 67404 Illkirch cedex, France
The glucocorticoid receptor (GR) and the tumor supressor p53 mediate different stress responses. We have
studied the mechanism of their mutual inhibition in normal endothelial cells (HUVEC) in response to
hypoxia, a physiological stress, and mitomycin C, which damages DNA. Dexamethasone (Dex) stimulates the
degradation of endogeno
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