MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells.PDFVIP

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MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells.PDF

MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells.PDF

MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells John L. Goodier*, Ling E. Cheung, Haig H. Kazazian Jr. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Abstract MOV10 protein, a putative RNA helicase and component of the RNA–induced silencing complex (RISC), inhibits retrovirus replication. We show that MOV10 also severely restricts human LINE1 (L1), Alu, and SVA retrotransposons. MOV10 associates with the L1 ribonucleoprotein particle, along with othe

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