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MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells.PDF
MOV10 RNA Helicase Is a Potent Inhibitor of
Retrotransposition in Cells
John L. Goodier*, Ling E. Cheung, Haig H. Kazazian Jr.
McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Abstract
MOV10 protein, a putative RNA helicase and component of the RNA–induced silencing complex (RISC), inhibits retrovirus
replication. We show that MOV10 also severely restricts human LINE1 (L1), Alu, and SVA retrotransposons. MOV10 associates
with the L1 ribonucleoprotein particle, along with othe
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