原创力文档Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of β-catenin.PDFVIP
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Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of β-catenin.PDF
Nuclear-cytoplasmic shuttling of Axin regulates
subcellular localization of -catenin
Feng Cong* and Harold Varmus
Cancer Biology and Genetics Program, Sloan–Kettering Institute, Memorial Sloan–Kettering Cancer Center, New York, NY 10021
Contributed by Harold Varmus, December 31, 2003
Wnt signaling regulates many aspects of development by increas- the output of Wnt signaling is highly sensitive to the turnover rate
ing the signaling activity of -catenin. Axin is a negative regulator of Axin (13). Indeed, it has been shown that Wnt signaling
of the W
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