钯催化的官能团导向的sp2-C—H键功能化有机化学.pdfVIP

DOI: 10.6023/cjoc201209022 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 2 钯催化的官能团导向的sp -C—H 键功能化 李丹丹a 何程林a 蔡海婷a 王官武*,a (a 中国科学技术大学化学系 合肥 230026) 摘要 近年来, 钯催化的 C—H 键功能化已成为有机合成中构建 C—C 键, C—N 键, C—O 键, C—X (Cl, Br, I)键等的重 要方法, 而带有导向基团的 C—H 键的选择性功能化一直备受关注. 主要综述了通过官能团导向实现 sp2-C—H 键功能 化的最新研究进展, 介绍了各类反应的特点、优势及在合成中的应用. 关键词 钯催化; 导向; sp2-C—H 键活化; 功能化; 偶联反应 2 Palladium-Catalyzed Group-Directed sp -C—H Functionalization Li, Dandana He, Chenglina Cai, Haitinga Wang, Guanwu*,a a ( Department of Chemistry, University of Science and Technology of China, Hefei 230026) Abstract Recently, palladium-catalyzed direct C—H bond functionalization has emerged as the most useful and important methods to construct C—C bond, C—N bond, C—O bond and C—X (Cl, Br, I) bond in organic synthesis. Directing group-assisted selective activation of C—H bond has been received increasing attention. This review mainly covers the recent 2 advances in the versatility and practicality of directing group-assisted sp -C—H functionalization. 2 Keywords palladium-catalyzed; ligand-directed; sp -C—H bonds activation; functionalization; cross-coupling reaction 在过去的几十年里, 过渡金属催化的偶联反应一直 X R2 R2 1