Notch信号与心脏干细胞关系研究进展_蒋晓帆_丁然然_姜汉国_揭伟.pdfVIP

Chinese Journal of Cell Biology 2014, 36(6): 818–825 DOI: 10.11844/cjcb.2014.06.0391 Notch (, 524023) Notch, (cardiac stem cells, CSCs) , Notch, Notch, Notch NotchCSCsCSCs NotchCSCs, CSCs Notch; ; ; ; ; Research Update of Relationship between Notch Signaling Pathway and Cardiac Stem Cells Jiang Xiaofan, Ding Ranran, Jiang Hanguo*, Jie Wei* (Department of Pathology, School of Basic Medicine Sciences, Guangdong Medical College, Zhanjiang 524023, China) Abstract Notch signaling is a highly conserved signaling pathway in a wide variety of animal cells, which plays an important role in stem cells biology. Cardiac stem cells (CSCs) are multipotent cells which locate in the niche of heart. Notch receptors are distributed on the CSCs membrane and the neighboring cells express Notch ligand, suggesting Notch signaling in CSCs could be re-activated under certain conditions. In the present paper, we reviewed the composition and activation of the Notch signaling pathway, the defi nition and origin of CSCs, the general biological characteristics of the main types of CSCs and the relationship between Notch signaling pathway and the formation, differentiation and proliferation of CSCs, as well as the perspectives of CSCs in the myocardial regeneration by CSCs transplantation. Key words Notch signaling pathway; cardiac stem cells; origin; differentiation; proliferation; myocardial regeneration Notch , , , (cardiac stem cells, CSCs)(cardiac progenitor cells, : 2013-11-26 : 2014-02-14 (: CPCs), *Tel: 0759-2388584, E-mail: J