聚谷氨酸聚吡咯复合纳米颗粒制备及神经毒性研究.pdfVIP

Material Sciences 材料科学, 2013, 3, 125-131 doi:10.12677/ms.2013.33024 Published Online May 2013 (/journal/ms.html) Preparation of PGlu/PPy Composite Nanoparticles and Neurotoxicity Evaluation * Jingwen Zeng, Zhongbing Huang , Guangfu Yin College of Materials Science and Engineering, Sichuan University, Chengdu * Email: zbhuang@ Received: Apr. 6th th rd , 2013; revised: Apr. 8 , 2013; accepted: May 3 , 2013 Copyright © 2013 Jingwen Zeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract: Polypyrrole (PPy) nanoparticles doped with poly(glutamic acid) (PGlu) or PGlu/sodium dodecyl sulfate (SDS) were prepared by oxidation polymerization. The PPy nanoparticles were characterized via standard four-probe setup, FT-IR, SEM, Laser Particle Size Analyzer (LPSA) and zeta CAD. In order to evaluate the cytotoxicity and neu- rotoxicity, the PPy particles were co-cultured with L929 and PC12, respectively. The results show that the dopants have an effect on the morphology and conductivity of PPy nanoparticles. PGlu doped PPy nanoparticles have good cell compatibility. The addition of SDS is beneficial to improve the conductivity of PPy nanoparticles, however it is slightly to the disadvantage of cell viability and neuron growth. Keywords: PPy Nanoparticle; Neurotoxicity; Neural Outgrowth; PGlu; SDS 聚谷氨酸/聚吡咯复合纳米颗粒的制备及神经毒性研究