lecture9_Molecularrecognition分子识别.pdfVIP

Lecture 9 Molecular recognition Antoine van Oijen BCMP201 Spring 2008 Structural principles of binding 4 fundamental functions of proteins: 1) Binding 2) Catalysis 3) Switching 4) Structural All involve binding! Last week: Kinetics and thermodynamics of binding Today: Structural principles of binding 1 The nature of protein-protein interactions Binding energy simply sum of energies of - hydrogen bonds - ionic contacts