09 HLA与疾病素材.pptVIP

HLA 与 疾 病 近年免疫遗传学表明免疫与遗传有关，基因表达量的异常可以引起免疫功能的紊乱，导致免疫性疾病的发生，这为探讨免疫性疾病的发病机制开辟了新途径。 Drugs and ADRs (药物与急性皮肤反应) HLA-B*1502 Prevalent in Asia The risk of SJS/TEN is estimated to be about 1 to 6 per 10,000 new users in countries with mainly Caucasian population. The risk increases about 10 times higher among Asian Countries Variation within Asia Exists Greater than 15% of the population is reported positive in Hong Kong, Thailand, Malaysia and parts of the Philippines South Asians, including the Indians, appear to have intermediate prevalence of HLA-B*1502, averaging 2 to 4%, but higher in some group