利福昔明乳房注剂对干奶期奶牛临床性乳房炎预防效果的观察.pdfVIP

摘 要 目的：本研究旨在观察利福昔明乳房注入剂对奶牛临床型乳房炎的预防效 果。 方法：选择非临床型乳房炎的泌乳末期健康奶牛共计 75 头，随机分成 5 组， 每组 15 头：1 个空白对照组，即健康不给药对照组；1 个药物对照组，即苄星氯 唑西林乳房注入剂组；3 个受试药物组分别为利福昔明乳房注入剂高、中、低三 个剂量组。分别在干乳期、泌乳期观察了受试奶牛的临床症状及临床型乳房炎发 生情况；采用微生物学常规技术检测了给药前后牛乳中的致病菌数量；采用 CMT 法和体细胞计数（SCC）法检测了牛乳中的体细胞计数；采用兽用全自动血液细 胞分析仪检测牛血液常规；采用兽用血液生化分析仪检测奶牛肝肾功能；采用兽 用尿液分析仪检测奶牛尿常规；观察记录奶牛增重及饲料转化率。 结果：低剂量、中剂量和高剂量的利福昔明乳房注入剂对试验奶牛乳区的保 护率分别为 95.00% ，96.67%和 98.33% ，其中低剂量组显著高于空白对照组 （P0.05 ），中剂量组和高剂量组均极显著高于空白对照组（P0.01 ）；低剂量、 中剂量、高剂量的利福昔明乳房注入剂灌注试验奶牛乳区后，均能显著的降低乳 中金黄色葡萄球菌、链球菌及大肠杆菌的数量（P0.05 ）；低剂量、中剂量及高 剂量的利福昔明乳房注入剂均能显著降低泌乳后不同时间乳中 SCC 和CMT 的数 量（P0.05 ）。 结论：不同剂量的利福昔明乳房注入剂对临床型奶牛乳房炎均有较好的预防 效果，可显著降低奶牛乳房炎的发生率。 关键词：利福昔明；奶牛；干乳期；临床型乳房炎；预防效果 Observation on Preventative Effects of Rifaximin Intramammary Infusion for Clinical Mastitis in Dairy Cows Abstract Objective: this experiment was conducted to study the Prophylactic efficacy of Rifaximin intramammary infusion on clinical mastitis in dairy cows. Seventy-five late lactation cows with non-clinical mastitis were randomly assigned to five groups and fifteen cows each group: blank control group (health control group); positive control group (drug control group); three treatment groups with high dose, medium dose and low dose. Methods: we respectively observed the incidence rate of the clinical symptom and the clinical Mastitis in tested dairy cows at the dry period and lactation period ， detected the numbers of the pathogenic bacteria before and after each dose by the way of the microbiology technology，detected the cell mumbers in the milk adopting the CMT and SCC. The automatic blood cell analyzer of beasts was applied to determine the blood routine of dairy cows. The blood biochemical analyzer of beasts was applied to determine the examination of liver and renal function of dairy cows. The