N_取代苯并咪唑酯类衍生物的合成及表征.pdfVIP

() 2010 10, 40 5, O ct., 2010, Vol. 40, No. 5 Journal ofNorthwestUniversity (Natural Science dition) N 马珊珊, 姜 珊, 邵欣欣, 陈 伟, 杨秉勤 ( /, 710069) : 合成苯并咪唑酯及其衍生物, 并对其合成方法进行改进研究 以 苯二胺为起 始原料合成了苯并咪唑2甲酸乙酯( 1)和苯并咪唑2乙酸乙酯( 2),再以丙酮为溶剂, 分别与乙酰 氯, 苯甲酰氯和二茂铁甲酰氯常温反应 3 h 合成了N取代苯并咪唑2甲酸乙酯酰胺衍生 1 物( 1a1c), N取代苯并咪唑2乙酸乙酯酰胺衍生物( 2a- 2c), 并通过 IR, H NMR, MS和元素分析 确定了分子结构 合成方法简便易行产率高, 为进一步形成配合物奠定了良好基础 : 苯并咪唑酯; 衍生物;合成;表征 : O621. 3 : A : 1000274 ( 2010) The synthesis and characterization of derivatives of Nbenzim idazolylacetates MA Shanshan, JIANG Shan, SHAO X inxin, CH N W e,i YANG BingQ in (Key Laboratory of Synthetic and NaturalFunctionalM olecule Chem istry (M inistry of ducation), College of Chem istry andM aterials Science, Northw estUniversity, X i an 710069, China) Abstract: A im To make mi provement on the synthetic method of benzmi idazolyacetates and their corresponding derivatives. M ethods Synthesizing ethyl2benzmi idazolecarboxylate( 1) and ethyl 2benzmi idazolyacetate( 2) from readily available materials ophenylendiam ine, and thenmaking both of them reacted with acetyl chloride, benzoyl chloride and ferrocenylcarbonyl chloride respectively at room temperature for3h in acetone. Results Derivatives of Nethyl 2benzmi idazolecarboxylate am ide ( 1a1c) and Nethyl 2benzmi idazolyacetate am ide ( 2a2c) were ob 1 tained w ith a good yield, and themolecular structureswere confirm ed by IR, HNMR, MS and elemental analysis. Conclusion The synthetic m ethod has the advantages of high yield and ease of preparation, which laid a solid foundation for the further synthesis of coordination compounds. K ey words: benzmi idazolylacetates; derivativ