干细胞癌症精要.pptVIP

* * * * * * * * * * Leukemic stem cells (LSC): Classic examples of CSC Lapidot T, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645-648, 1994. Blair et al., Blood 89, 3104-3112, 1997 Bonnet, D., Dick, J.E. Nature Med. 3, 730-737, 1997 Most of the leukemic cells are unable to proliferate extensively and only a small, defined subset of cells was consistently clonogenic. LSCs for human AML were identified prospectively and purified as [Thy1-, CD34+, CD38-] cells from various patient samples and they represent 0.2 - 1% of the tota