牛传染性胸膜肺炎弱毒疫苗和微量凝集诊断技术研究回顾与展望.pdfVIP

中国农业科学 2007,40(增刊1):439-443 Scientia Agricultura Sinica 牛传染性胸膜肺炎弱毒疫苗和微量凝集诊断技术 研究回顾与展望 辛九庆 （中国农业科学院哈尔滨兽医研究所/兽医生物技术国家重点实验室，哈尔滨 150001） 摘要：牛传染性胸膜肺炎（Contagious Bovine Pleuropneumonia CBPP）曾于20 世纪50 年代开始在中国大 面积流行，造成了巨大的经济损失。随后在50 年代末随着牛肺疫兔化弱毒菌苗、兔化绵羊化适应菌苗和微量凝集 诊断技术的研制成功和广泛应用，使牛传染性胸膜肺炎得到了有效的控制，并逐步地在中国消灭CBPP。为此，由 吴庭训教授和吴裕祥教授分别主持研究开发的研究成果“牛肺疫兔化弱毒菌苗、兔化绵羊化适应菌苗和微量凝集 诊断技术”1999 年获得国家发明二等奖。本文对该项成果的历史背景、社会需求、学术价值、研究水平进行了介 绍，同时对该成果仍未解决的问题以及对相关疫苗研究所起的借鉴作用进行了讨论。 关键词：牛传染性胸膜肺炎；兔化绵羊化适应菌苗；微量凝集诊断技术 Review and Prospect of Eradicating Contagious Bovine Pleuropneumonia XIN Jiu-qing (National Key Laboratory of Veterinaoy Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001) Abstract: Contagious bovine pleuropneumonia (CBPP) was recorded in China early in 1920s. CBPP had been widespread in during the 1950’s, caused a great economic loss. In late 1950s, Wu Tingxun and Wu Yuxiang developed efficient vaccines and diagnostic technique. Since then CBPP was well controlled and gradually eradicated in China. The research achievements of Contagious Bovine Pleuropneumonia Lapinized vaccine, Lapinized sheep-adapted and Micro-Agglutination Diagnostic technique was granted Second-class National Invention Award in 1999. In this paper, the historical background, social demand, academic value, and research level of the achievement are described. Furthermore, the unsolved problems and the reference role of related vaccine research are discussed. Key words: Contagious bovine pleuropneumonia; Lapinized sheep-adapted vaccine; Micro-Agglutination diagnostic technique 牛传染性胸膜肺炎（