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action of disinfectant quaternary ammonium compounds against.pdf

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action of disinfectant quaternary ammonium compounds against

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 2007, p. 296–306 Vol. 51, No. 1 0066-4804/07/$08.00 0 doi:10.1128/AAC.00375-06 Copyright © 2007, American Society for Microbiology. All Rights Reserved. Action of Disinfectant Quaternary Ammonium Compounds against Staphylococcus aureus 1 2 3 Christopher J. Ioannou, * Geoff W. Hanlon, and Stephen P. Denyer 1 Quest International, Ashford, Kent TN24 0LT, United Kingdom ; School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, United Kingdom2; and Welsh School of Pharmacy, Cardiff University, Cardiff CF1 3XF, United Kingdom3 Received 27 March 2006/Returned for modification 21 July 2006/Accepted 17 October 2006 Mode-of-action studies concluded that alkyldimethylbenzylammonium chloride (ADBAC) (a blend of C12, D C14 and C16 alkyl homologues) and didecyldimethylammonium chloride (DDAC) are both membrane-active agents, possessing subtly different modes of action reflecting early cell interactions against Staphylococcus o aureus. ADBAC and DDAC exhibited similar MIC behaviors from 0.4 ppm to 1.8 ppm over an inoculum range w 5 9 n

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