Prefrontal cortex and basal ganglia control access to working.pdfVIP

A R T I C L E S Prefrontal cortex and basal ganglia control access to working memory Fiona McNab Torkel Klingberg Our capacity to store information in working memory might be determined by the degree to which only relevant information is remembered. The question remains as to how this selection of relevant items to be remembered is accomplished. Here we show that activity in the prefrontal cortex and basal ganglia preceded the filtering of irrelevant information and that activity, particularly in the globus pallidus, predicted the extent to which only relevant information is stored. The preceding frontal and basal ganglia activity were also associated with inter-individual differences in working memory capacity. These findings reveal a mechanism by which frontal and basal ganglia activity exerts attentional control over access to working memory storage in the parietal cortex in humans, and makes an important contribution to inter-individual differences in working memory capacity. Working memory capacity is an important factor for a wide range of as distractors to be ignored (the ‘distraction’ condition) or target cognitive abilities, including general fluid intelligence1,2. Recent studies stimuli to be remembered (the ‘no distraction’ condition) in the of humans using functional magnetic resonance imaging (fMRI) and subsequent working memory task (Fig. 1). In the distraction task, electroencephalography have identified a region in the parietal lobe subjects needed to remember three red circles (targets) and ignore two where brain activity reflects the amount of stored visuo-spatial infor- yellow circles (distractors). In the no distraction task, the number of mation3,4. Furthermore, subsequent studies ha