室房逆传对窦房功能及心房肌电活动影响的实验研究.pdfVIP

: VAC : 40 32 200 /11VAC (22 )1 1VAC 10 1h2h4h,7d 11VAC 1hP0.01 P0.05 2hP0.01P0.01 P0.01P0.014h P0.0017dP0.05 P0.00111VAC 1hP0.01 P0.052h4h P0.01 P0.057dP0.05 P0.05 P0.0511VAC 11VAC1h P0.0511VAC P0.05P0.052h P0.0511VACP0.01 P0.014h7dP0.05 11VAC P0.001 VAC VAC II Abstract Objective: The aim of the study was to investigate the influences of ventricular atrial conduction(VAC) on functions of sinoatrial node and atrial electrical activities in rabbit sinus node dysfunction model. Methods: Sinus node dysfunction models were made in 32 health rabbits. The rabbits were divided into 1:1 VAC group and non 1:1 VAC group by pacing right ventricle at 200 beat percent minute(bpm). The changes of right atrial pressure, atrial effective refractory period,atrial activity time,wave length index and corrected sinus node recovery time were examined at 1, 2, 4 hours and 7 days after pacing. Results: (1)1:1 VAC auto-randomized controlled group: At one hour of pacing right atrial pressure was increased significantly (p0.01)however there were no significant differences in atrial effective refractory period, atrial activity time, wave length index and corrected sinus node recovery time (p 0.05). At 2 hours of pacing right atrial pressure continued to step-up(p0.01), atrial effective refractory period and wave length index decreased (p0.01) while corrected sinus node recovery time and atrial activity time increased respectively (p0.01).The changes of right atrial pressure, atrial effective refractory period, atrial activity time, wave length index and cor