a pathoanatomic approach to the management of mitral regurgitation：对二尖瓣反流的病理学方法管理.pdf

T R E N D S I N C A R D I O V A S C U L A R M E D I C I N E ] ( 2 0 1 5 ) ] ] ] – ] ] ] Available online at /locate/tcm A pathoanatomic approach to the management of mitral regurgitation n Vinay Badhwar , Anson J.C. Smith, and João L. Cavalcante The Center for Mitral Valve Disease, Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA a b s t r a c t Mitral regurgitation remains the most common global valvular heart disease. From otherwise unsuspecting healthy patients without overt symptoms to those with recalcitrant heart failure, mitral valve (MV) disease touches millions of patients per year. While MV prolapse without regurgitation remains benign, once regurgitation begins, quantification of severity is related to prognosis. Under- standing the mechanism of regurgitation guides appropriate treatment. Current management guidelines emphasize early therapy after careful assessment of both anatomy and severity of mitral regurgitation. The objective of this review is to provide an update on the treatment of MV disease and to offer additional granularity on pathoanatomic decision making that may aid a more precise application of optimal guideline-directed therapy of primary and secondary mitral regurgitation. Key Words: Mitral valve disease, Mitral regurgitation, Diagnosis, Management, Surgery. 2015 Elsevier Inc. All rights reserved. Mitral regurgitation represents the most common valvular The increased prevalence of MV disease coupled with several disease affecting more than 2 million people in t