原创力文档a randomized, double-blind, dose-finding, multicenter, phase 2 study of radium chloride (ra 223) in patients with bone metastases and castration-resistant prostate cancer：一项随机，双盲，剂量发现，多中心，2期研究中的镭-氯（镭223）在骨转移和去势抵抗前列腺癌患者.pdfVIP
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a randomized, double-blind, dose-finding, multicenter, phase 2 study of radium chloride (ra 223) in patients with bone metastases and castration-resistant prostate cancer：一项随机，双盲，剂量发现，多中心，2期研究中的镭-氯（镭223）在骨转移和去势抵抗前列腺癌患者
E U R O P E A N U R O L O G Y 6 3 ( 2 0 1 3 ) 1 8 9 – 1 9 7
ava ilable at
journal homepage: www.eu
Platinum Priority – Prostate Cancer
Editorial by Joaquim Bellmunt on pp. 198–200 of this issue
A Randomized, Double-Blind, Dose-Finding, Multicenter,
Phase 2 Study of Radium Chloride (Ra 223) in Patients with
Bone Metastases and Castration-Resistant Prostate Cancer
a, * b ˇ c d ´ e
Christopher C. Parker , Sarah Pascoe , Ales Chodacki , Joe M. O’Sullivan , Josep R. Germa ,
Charles Gillies O’Bryan-Tearf , Trond Haider g, Peter Hoskin h
a Royal Marsden Hospital, Sutton, UK; b Derriford Hospital, Plymouth, UK; c Hospital Chomutov, Chomutov, Czech Republic; d Centre for Cancer Research and
Cell Biology, Queen’s University Belfast, Belfast, Northern Ireland, UK; e ` f
IDIBELL Institut Catala d’Oncologia, I’Hospitalet Barcelona, Barcelona, Spain; Algeta
ASA, Oslo, Norway; g LINK Medical Research AS, Oslo, Norway; h Mount Vernon Hospital, Middlesex, UK
Article info Abstract
Article history: Background: Patients with castration-resistant prostate cancer (CRPC) and bone
Accepted September 3, 2012 metastases have an unmet clinical need for effective treatments that improve quality
Published online ahead of of life and survival with a favorable safety profile.
Objective: To prospectively evaluate the efficacy and safety of three different doses of
print on September 13, 2012 radium chloride (Ra 223) in patients with CRPC and bone metastase
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