a rare and unique case of aggressive ige-λ plasma cell myeloma in a 28-year-old woman presented initially as an orbital mass：一种罕见的侵袭性ige独特的案例λ浆细胞骨髓瘤在一个28岁的女人，最初的轨道质量.pdfVIP

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a rare and unique case of aggressive ige-λ plasma cell myeloma in a 28-year-old woman presented initially as an orbital mass：一种罕见的侵袭性ige独特的案例λ浆细胞骨髓瘤在一个28岁的女人，最初的轨道质量.pdf

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a rare and unique case of aggressive ige-λ plasma cell myeloma in a 28-year-old woman presented initially as an orbital mass：一种罕见的侵袭性ige独特的案例λ浆细胞骨髓瘤在一个28岁的女人，最初的轨道质量

Human Pathology (2012) 43, 2376–2384 /locate/humpath Case study A rare and unique case of aggressive IgE-k plasma cell myeloma in a 28-year-old woman presented initially as an orbital mass a b b a Ke Li MD , Grace Ku MD , Min Yan MD , H. Elizabeth Broome MD , Michael Kelner MD, MS a, Huan-You Wang MD, PhD a,⁎ aDepartment of Pathology, University of California San Diego Health System, La Jolla, CA 92093–0987, USA bDepartment of Medicine, Division of Hematology/Oncology, University of California San Diego Health System, La Jolla, CA 92093–0960, USA Received 30 March 2012; revised 13 June 2012; accepted 6 July 2012 Keywords: Summary A 28-year-old African-American woman presented with new onset of left exophthalmos and IgE; diplopia. Computed tomography of the head showed a solitary mass in the left orbit. Excisional biopsy Plasma cell myeloma revealed a diffuse infiltrate composed of exclusively λ-restricted monotypic plasma cells based on morphology and immunohistochemistry, consistent with a plasma cell neoplasia. A subsequent staging bone marrow biopsy showed involvement of the bone marrow by λ-restricted monotypic plasma cells, consistent with a plasma cell myeloma. Serum protein electrophoresis and immunofixation studies on the peripheral blood showed a monoclonal band of IgE-λ; thus, an IgE-λ plasma cell myeloma was established. Addition