a role for the bdnf gene val66met polymorphism in schizophrenia a comprehensive review：对bdnf基因val66met多态性在精神分裂症的全面审查的作用.pdfVIP

Neuroscience and Biobehavioral Reviews 51 (2015) 15–30 Contents lists available at ScienceDirect Neuroscience and Biobehavioral Reviews j o u r n a l h o m e p ag e: w w w. elsev /locate/neubiorev Review A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review Michael Notaras a,b , Rachel Hill a,b , Maarten van den Buuse a,c,d,∗ a Behavioural Neuroscience Laboratory, Florey Institute of Neuroscience Mental Health, VIC, Australia b Psychoneuroendocrinology Laboratory, Florey Institute of Neuroscience Mental Health, VIC, Australia c Department of Pharmacology Therapeutics, University of Melbourne, VIC, Australia d School of Psychological Science, La Trobe University, VIC, Australia a r t i c l e i n f o a b s t r a c t Article history: Schizophrenia is believed to arise from complex gene–environment interactions. Brain-derived neu- Received 22 May 2014 rotrophic factor (BDNF) is involved in neuronal development, differentiation and plasticity. A functional Received in revised form single nucleotide polymorphism that results in a valine (Val) to methionine (Met) substitution at codon 14 November 2014 66 (Val66Met) results in the aberrant sorting and release of mature BDNF through the activity-dependent Accepted 27 December 2014 secretion pathway. The Val66Met polymorphism has been linked to impaired neurocognitive function Available online 3 January 2015