a series of infections due to capnocytophaga spp：一系列由于二氧化碳噬纤维菌属感染. in immunosuppressed and immunocompetent patients.pdfVIP

ORIGINAL ARTICLE A series of Infections due to Capnocytophaga spp. in immunosuppressed and immunocompetent patients 1 2 3 2 ¨ 4 4 1 5 H. Bonatti , D. W Rossboth , D. Nachbaur , M. Fille , C. Aspock , I. Hend , K. Hourmont , L. White , H. Malnick6 and F. J. Allerberger6 1Department for General and transplant Surgery, 2Institute for Hygiene, 3Department for Clinical Immunobiology and BMT, Medical Division, University of Innsbruck, Innsbruck, Austria; 4Clinical Institute for Hospital Infection Control, University of Vienna, General Hospital Vienna, Vienna, Austria; 5Southmead Hospital, UK NEQAS for Antibiotic Assays, Department for Microbiology, Southmead Health Services NHS Trust, Bristol and 6Central Public Health Laboratory, London, UK Objective To investigate the epidemiology, microbiology and outcome of infections caused by Capnocytophaga spp. at a single center. Methods We report on ten documented infectious episodes caused by Capnocytophaga observed between 1994 and 1999 at the Innsbruck University Hospital. Results In seven of ten patients, Capnocytophaga septicemia was diagnosed during periods of neutropenia. In contrast, the remaining three patients had normal white blood cell counts when acquiring Capnocytophaga septicemia (one) and pleural empyema (two). Blood cultures containing long, slender, Gram-negative rods, which grew slowly under anaerobic conditions and lacked susceptibility to metronidazole, were subculti- vated in a CO2-enriched atmosphere (5%). Subcultivation yielded Capnocytophaga in all ten cases within 2–12 days. The patients were then placed on appropriate antibiotic therapy, with or without additional