a simple method for examination of polymorphisms of catalase exon 9 rs769217 in hungarian microcytic anemia and beta-thalassemia patients：对过氧化氢酶基因外显子9 rs769217匈牙利小细胞性贫血和β-地中海贫血患者多态性检查的一种简单方法.pdfVIP

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a simple method for examination of polymorphisms of catalase exon 9 rs769217 in hungarian microcytic anemia and beta-thalassemia patients：对过氧化氢酶基因外显子9 rs769217匈牙利小细胞性贫血和β-地中海贫血患者多态性检查的一种简单方法.pdf

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a simple method for examination of polymorphisms of catalase exon 9 rs769217 in hungarian microcytic anemia and beta-thalassemia patients：对过氧化氢酶基因外显子9 rs769217匈牙利小细胞性贫血和β-地中海贫血患者多态性检查的一种简单方法

Archives of Biochemistry and Biophysics 525 (2012) 201–206 Contents lists available at SciVerse ScienceDirect Archives of Biochemistry and Biophysics journal homepage: /locate/yabbi A simple method for examination of polymorphisms of catalase exon 9: rs769217 in Hungarian microcytic anemia and beta-thalassemia patients Teréz Nagy, Melinda Csordás, Zsuzsanna Kósa, László Góth ⇑ Department of Biomedical Laboratory and Imaging Science, Medical and Health Science Center, University of Debrecen, P.O. Box 55, Debrecen H-4012, Hungary a r t i c l e i n f o a b s t r a c t Article history: Catalase decreases the high, toxic concentrations of hydrogen peroxide but it lets the physiological, low Available online 20 January 2012 concentrations in the cells mainly for signaling purposes. Its decreased activity may contribute to devel- opment of several pathological conditions. Catalase mutations occur frequently in exon 9, these were Keywords: examined with different, complicated and costly methods. Catalase gene mutations screening The aim of the current study was to evaluate a method for screening of polymorphisms in catalase exon 9. SSCP We used the slab gel electrophoresis of PCR amplicons without denaturation and silver staining for visu- Microcytic anemia alization of the DNA bands. We detected extra DNA bands in the 400–800 bp region of the catalase exon 9. Beta-thalassemia Acatalasemia