5-羟甲基胞嘧啶研究分析进展.pdfVIP

HEREDITAS (Beijing) 2012 5 , 34(5): 509―518 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2012.00509 5-羟甲基胞嘧啶的研究进展 张燕霞, 高可润, 禹顺英 , 200030 CpG 二核苷酸中胞嘧啶的甲基化形式5- 甲基胞嘧啶(5-methylcytosine, 5mC)在哺乳动物中是一种常见的 表观遗传修饰, 在基因表达调控、发育调节、基因组印迹等方面发挥重要作用。近3 年来研究发现, 除了5mC 外, 胞嘧啶碱基的另一种修饰—5-羟甲基胞嘧啶(5-hydroxymethylcytosine, 5hmC)在哺乳动物的多种组织中有着 丰富的表达, 它可能与5mC 有着不同的生物学功能。文章就近年来5hmC 的研究进展进行了综述。 5-羟甲基胞嘧啶; TET 蛋白; 表观遗传 Progress of research on 5-hydroxymethylcytosine ZHANG Yan-Xia, GAO Ke-Run, YU Shun-Ying Shanghai Mental Health Center, School of Medicine,Shanghai Jiao Tong University, Shanghai 200030, China Abstract: 5-methylcytosine (5mC) in cytosine-guanine dinucleotide (CpG) is a usual epigenetic modification in mam- mals. It plays crucial roles in gene regulation, development, genomic imprinting and so on. In the last three years, it was discovered that in addition to 5mC, another modified cytosine base—5-hydroxymethylcytosine (5hmC) was abundant in many mammalian tissues, which may have different biological function from 5mC. This paper reviews the recent progresses in the studies of 5hmC. Keywords: 5-hydroxymethylcytosine; TET protein; epigenetics 5- (5-hydroxymethylcytosine, , DNA 15%, 5hmC) 5-(5-methylcytosine, 5mC) [3], 2009 , 1952 DNA , Tahiliani[4] Kriaucionis[5] , Science 5hmC [1] , 1972 Penn[2](Rattusnorvegicus) 5hmC5mC (Musmusculus) 5 6 (Ranacatesbiana) DNA 5hmC, 收稿日期: 2011−08−29; 修回日期: 2011− 12−04 基金项目: 作者简介: ,