复方三七通脉片治疗缺血性脑血管病的作用机理的研究.pdf

环 ，保护脑缺血动物 ，抗血栓 、抗血凝 、抗血小板聚集和促进纤溶、促使血栓再通 的 作用 。对大 鼠脑缺血有 明显的保护作用 ，减少梗死区，保护缺血区神经元，改善脑功 关键词 复方三七通脉片；急性毒性 ；脑膜微循环 ；急性脑缺血 ；脑指数 ；血栓 ; 血瘀 ；中动脉 结扎 ；实验研 究 M ech an ism of com p ou n d S an q i T on gm ai tab let in th e treatm en t of isch em ic c e r eb r o v a sc u la r d ise a se a S p eciality ： C h in ese D rug Pharm acology A u th or ： M in Z h an g T u to r ： G u i-h a i L i A b str a c t O bjective ： B y ob serv ing the acute toxicity of the com pound Sanqi T ongm ai T ab let on m ice in order to understand th e tox icity and safety of th e prep arations ;B y ob serving b lood flow effcts on th e rats m en ingeal m icrocircu lation ，the effcts of in acute hyp ox ic state ， th e brain index and w ater content effcts in acu te in com p lete cerebral ischem ia m odel in rat ， exp lore its m echanism . T hrough ob servation of throm bosis, b lood stasis m odel rats in v ivo an ti-throm b otic, anti-b lood clottin g ，prom ote fibrino ly sis and other ind icators, and further exp lore th e m echan ism of th e treatm ent of isch em ic cerebrovascu lar disease in th is produ ct.B y ob serving the signs on the nerves of M C A O rats, learn ing and m em ory fun ction, vasoactive sub stances, oxygen free radicals and brain tissu e m orpho logy, etc. to exp lore the m ech anism of the treatm ent for isch em ic cerebrovascu lar disease. M eth od s： G iv e m ice th e com pound Sanqi T ongm ai p iece 30% su spension of 0.4 g / k g orally ，and as th e m axim um to lerated dose m eth od to ob serve th e acute tox icity of th is produ ct; In accordan ce w ith th e com pound Sanq i T ongm ai tab let 4 tim es 2 tim es 1 tim es of th e clin ical equ ivalent of preparation of th e investigational drug. W e bu ilt m en ingeal m icrocircu lation m odel of rats, m ice m odel in acute hyp ox ia ; rats w ith acute in com p lete cer