α-硫辛酸对实性自身免疫性脑脊髓炎大鼠轴索损伤的保护作用.pdf

、 · 、、．、，、． ，t ＼＼ ‘～ ‘≈ 目 录 中文摘要……………………………………………………………………1 英文摘要……………………………………………………………………5 研究论文 Q．硫辛酸对实验性自身免疫性脑脊髓炎大鼠轴索损伤 的保护作用 前言刖吾 …···………………………………………………………···…10””“”“…””一…””一””“”””…”””””””“”““””“””10 材料与方法………”…………………………………………………·10 结果··················……······…………········…····…··················17 附图…········…·······················…·····························…······22 00000 附表0 0······………………………………………………···35 000 00oa 讨论··················…···…·········0 000000 o···························38 小结···············0000000000000000a0…………························……···41 参考文献………………………………………………………………41 综述 氧化应激与多发性硬化的轴索损伤………………………………45 致谢····································…·············································56 eoOoooooOoooo0………………………………………”……………·57 个人简历O 中文摘要 辛酸对实验性自身免疫性脑脊髓炎大鼠轴索损伤 的保护作用 摘 要 目的：多发性硬化(multiple nervous 统(central 以CNS广泛的髓鞘脱失而轴索结构相对保存为特征的原发性脱髓鞘病变。 直到上世纪九十年代末期国外学者证实在MS急性和慢性病灶中均存在轴 索损伤，受损轴索多存在于硬化斑内或其边缘，在大体形态正常的白质中 也有少量的轴索破坏。病灶中的轴索损害引起wanerina变性，导致轴索缺 失。目前认为轴索变性或损害是M