益生菌治疗下消化道病症国际参考指南.pdf

Alimentary Pharmacology and Therapeutics Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence- based international guide ,† ‡,§,¶, †† ‡‡ §§ ¶¶ A. P. S. Hungin*, C. Mulligan* , B. Pot **, P. Whorwell , L. Agreus , P. Fracasso , C. Lionis , J. Mendive***, J.-M. Philippart de Foy†††, G. Rubin*, C. Winchester† N. de Wit‡‡‡ for the European Society for Primary Care Gastroenterology *School of Medicine, Pharmacy and SUMMARY Health, Durham University, Stockton-on- Tees, UK. † Research Evaluation Unit, Oxford Background TM Ltd, Oxford, UK. PharmaGenesis Evidence suggests that the gut microbiota play an important role in gastrointestinal ‡Institut Pasteur de Lille, Centre for problems. Infection and Immunity of Lille, Lille, France. § Universite Lille Nord de France, Lille, Aim France. ¶ CNRS UMR 8204, Lille, France. To give clinicians a practical reference guide on the role of specified probiotics **INSERM U1019, Lille, France. in managing particular lower gastrointestinal symptoms/problems by means of a ††Centre for Gastrointestinal Sciences, systematic review-based consensus. University of Manchester, Wythenshawe Hospital, Manchester, UK. Methods ‡‡Centre for Family Medicine, Karolinska Institute, Stockholm, Sweden. Systematic literature searching identified randomised, placebo-controlled trials in §§Gastroenterology Unit, Don Bosco adults; evidence for each symptom/problem was graded and