止咳胶囊治疗咳变异性哮喘气阴两虚型的临床研究.pdfVIP

The Clinical Study on Treating Cough Variant Asthma of Qi and Yin deficiency with Cough capsule Speciality: The Study of Lung Disease Internal Medicine of TCM Author: Chen Yangkai Tutor: Professor Chen Xianhai Abstract Objective:To observe and evaluate the cilnical security and validity of Cough capsule in treating Cough Variant Asthma (which belongs to Qi and Yin deficiency type in TCM) and explore the mechanism of it. Methods: 60 patients were divided into two groups at random. 30 patients in observation group were treated with Cough capsule plus Doxofylline and Budesonide. 30 patients in control group were treated with Doxofylline and Budesonide. The related items were measured before and after the treatment.Results:The clinical study showed that there is a significant difference （P0.05 ） between the two groups.The effect of relieving airway inflammation,reducing the airway hyper-reaction and lung function and immunoregulation were improved more significantly in the treatment group than that in the control group. Conclusions: Cough capsule is an effective medicament of treating Cough Variant Asthma which can mdoderate the clinical sumptoms and prenvent it from transforming to asthma. Key words Yiqiyangyin Method ；Cough Variant Asthma ；Qi and Yin deficiency type；Clinical study 目 录 引 言 1 临床研究 2 一、临床研究 2 （一）诊断标准 2 （二）病例选择 2 （三）中医单项症状评分标准 3 （四）研究对象 4 二、研究方法 6 （一）治疗方法 6 （二）观察指标 6 （三）.观察方法 6 （四）疗效评定标准 7 （五）统计分析方法 7 三、研究结果 7 （一）咳嗽症状减轻、消退及夜间停止时间比较 7 （二）最大呼气流速峰值 (PEF) 占预计值百分比值治疗前后对比 8 （三）PEF 变异率治疗前后对比 8 （四）两组患者实验室检查结果治疗前后比较 9 （五）两组患者治疗前后症状积分比较 9 （六）两组患者中医证候疗效比较 10 （七）两组患者单项症状疗效比较 10 （八）安全性检测 11 讨 论 12 一、现代医学对咳嗽变异性哮喘的认识： 12 （一）发病机理 12 （二）病理改变 12 （三）治疗 13