火针治疗痤疮技规范化方案的临床评价研究.pdfVIP

目 录 1 耳尖刺血配艾灸治疗痤疮后色素沉着的临床研究„„„„„„1 1.1 中文摘要„„„„„„„„„„„„„„„„„„„„„„„1 1.2 英文摘要„„„„„„„„„„„„„„„„„„„„„„„3 1.3 前言„„„„„„„„„„„„„„„„„„„„„„„„„6 1.4 临床研究„„„„„„„„„„„„„„„„„„„„„„„8 1.5 结果„„„„„„„„„„„„„„„„„„„„„„„„„19 1.6 讨论„„„„„„„„„„„„„„„„„„„„„„„„„27 1.7 结论„„„„„„„„„„„„„„„„„„„„„„„„„33 1.8 参考文献„„„„„„„„„„„„„„„„„„„„„„„34 2 致谢„„„„„„„„„„„„„„„„„„„„„„„„„36 3 综述„„„„„„„„„„„„„„„„„„„„„„„„„37 火针治疗痤疮技术规范化方案的临床评价研究 中文摘要 目的：痤疮是一种常见的损容性疾病，约占皮肤科门诊量的30%，是 青春期常见的一种毛囊皮脂腺慢性炎症性皮肤病，好发于颜面部、胸 背部，可形成粉刺、丘疹、脓疱、结节、囊肿等严重损害,易反复发 作，重者常伴有瘢痕形成，严重影响美观，甚至出现自卑、焦虑、抑 郁、暴躁等心理异常。本研究旨在观察火针治疗痤疮的临床疗效，为 肯定火针治疗痤疮的临床疗效提供了可信度高的依据，制定严谨的科 学设计和评价方法，对火针治疗痤疮的方案进行临床研究，对形成操 作规范方案及指南具有临床指导意义和推广意义。方法：（1）本临床 研究采用多中心、随机对照研究，将入选的病例分为两组，每组最少 需样本例数n = 117，两组最少需总例数N =234，考虑脱落与失访原 因再扩大20%，治疗组、对照组病例均按 1：1 设立，共260 例。并 将全部入选患者按就诊顺序编号，采用SPSS 统计软件产生随机分配 方案。将随机分配方案隐藏（装入按序列编码的、密封的、不透光的 信封中）分配治疗，并作登记。（2）治疗组采用火针治疗，每5 天1 次，共治疗4 次。对照组采用西医疗法，早晚各 1 次，连续20 天。 （3）观察结束后将所有数据量化处理，运用统计软件SPSS19.0 进行 统计分析。结果：（1）本研究采用火针治疗结节囊肿性痤疮，结果显 示临床疗效肯定（痊愈率 16.8%,愈显率 79.2%，有效率96.8%），其 痊愈率、愈显率、有效率均明显高于西药组的治疗效果（痊愈率0.0%, 愈显率 15.2%，有效率87.8%），P=0.000。3 个中心的疗效率比较无 显著差异，P0.05。（2）2 种治疗方案都对粉刺、丘疹、脓疱、囊肿、 结节等皮损，对肿痛、颜色、油腻等评分有显著改善，在改善程度上， 以火针疗法更为明显。P=0.000。（3）两种治疗方案对各型痤疮的起 效时间上，以火针疗法为优，起效时间快于药物组。（4）两种治疗方 案均无明显不良反应。结论：本研究证实了该技术治疗各种类型痤疮 具有皮损消退迅速、清除病灶彻底、有效控制复发；技术安全可控、 操作规范、实用性强，易于推广使用等优点。为肯定火针治疗痤疮的 临床疗效提供了可信度高的依据。 关键词：痤疮 火针 临床评价 Clinical evaluation of the standardization program for fire-needle treatment of Acne Abstract:Objective:Acne is a common loss capacitive disease, accounts for about 30% of the MenZhen Liang dermatologist, adolescence is a common chronic inflammatory skin disease hair follicle sebaceous glands, good hair at face ministry, chest back, can form acne, papula, pustular, nodules, cyst serious damage, easy to break out repeatedly, the person that weigh is often