益气消癍汤治疗疫性血小板减少性紫癜的临床及实验研究.pdfVIP

The research of Yiqixiaobantang to the mechanism of the ITP Speciality : Internal Medicine of TCM Author: Zheng Hongmin Tutor: Proffessor Zhou Yanfeng Abstract Objective: To observe the Yiqixiaobantang’s curative effects of idiopathic thrombo- cytopenic purpura （Chronic Idiopathic Thrombocytopenic Purpura, ITP ）and its impact on the efficacy of ITP mouse model in IL-1 、IL-3、IL-6 effects, to explore the influence of traditional Chinese medicine therapeutic mechanism and provide the basis for clinical medication. Methods: Clinical observation: The 60 cases of idiopathic thrombocyto penia (ITP) were randomly divided into treatment combination of the control group, treatment group 30 cases, 30 control group, treatment group were treated with Yiqishengbantang group; control group Weixuening particles, two groups of treatment lasted about three months. Animal experiment: The 60 BALB/C mice were randomly divided into four groups, namely, the normal group, model group, Weixuening group, Yiqixiaobantang group. It is necessary to test four levels of serum IL-1 , IL-3 and IL-6 . Results: The clinical observation: The treatment group in total rate is 96.7%, the comparison group in total rate is up to 90.0%. the two groups had significant difference in total rate (P0.05); the treatment group and control group can effectively increase the number of platelets of patients, compared with those before treatment were significant differences (P0.01); platelets in total by treatment of two groups had significant difference (P0.05). The treatment group and control group can raise IL-3 level, and the treatment group better than control group (P0.05). Animal experiment: by the treatment, each group can