通络糖泰方对糖病周围神经病变患者感觉神经传导速度影响的临床研究.pdfVIP

中文摘要 目的:观察通络糖泰方对早期糖尿病周围神经病变患者 SNCV的影响,并探 讨其作用的可能机制. 方法:将40名气阴两虚兼瘀血阻络的DPN患者,随机分为治疗组(20例)和 对照组（20例）,两组患者都给予糖尿病基础治疗，对照组加弥可保口服，每次 0.5 mg,每日3次.治疗组在保持原糖尿病基础治疗的同时使用以益气养阴、化瘀 通络为主要功效的中药汤剂,每次150ml,每日3次,两组患者疗程均为8周;观察 治疗前后患者临床症状体征、空腹血糖、餐后2h血糖、糖化血红蛋白、感觉神 经传导速度等指标的变化,并对综合疗效进行评价. 结果:本研究显示入选DPN患者中，治疗组显效11例，有效8例，无效1 例，显效率为55％，总有效率为95％，对照组显效5例，有效10例，无效5例， 显效率为 25％，总有效率为75％患者症状明显改善。治疗组患者FPG、2hPG、 HbA1c、SNCV等指标有所下降，较治疗前有显著差异（p＜0.05）。对照组无明显 改变,两组治疗前后SNCV没有显著改变。 结论：通络糖泰方通过整体调节，能够有效改善DPN患者临床症状和体征 改善糖脂代谢，改善神经传导速度，从而起到早期防治DPN的作用。其综合疗效 优于对照组。 关键词：通络糖泰方 糖尿病周围神经病变 感觉神经传导速度（SNCV） 临床研究 中医药治疗 1 Abstract Objective: To observe the function and the possible mecha nism of Tongluotangtai Poly-pharmaceutical on how to regulate and influence the DPN patients, SNCV. Method: forty patients with DPN, who were Qi-Yin deficiency as root and blood stasis as appearance, were randomly divided into the treatment group(20 cases) and the control group(20 cases) by turn. All patients were treated with the basical treatment . The patients in control group were given Methycobal, every 0.5mg, 3 times. The patients in treatment group also were reveived the TCM decoction Tongluotangtai (150ml tid) with the main function of supplementing qi and nourishing yin and prompting blood circulation to dissipate blood stasis. Both groups were treated for 8 weeks.The symptoms and inflammatory factors of patients in two groups were observed before and after the treatment, including plasma concentrations of fasting blood glucemia (FPG)、2hPG、HbA1c、SNCV et al. Results: The clinical curative effective of symptoms in the treatment group: obvious effectiv