间质流膏治疗特性间质性肺炎的临床研究和实验研究.pdfVIP

Clinical Study and Experimental Study on the effect of jianzhi-liquid for idiopathic interstitial pneumonia Speciality: The research of Lung Disease. Medicine of TCM Author:Wang Qian Tutor:Professor Zheng Xin Abstract Objective: To study the clinical effect of jianzhi-liquid on idiopathic interstitial pneumonia(IIP) and levels of TGF-β1,TNF-α of serum, experiment research the mechanism of jianzhi-liquid. Methods: 90 cases of selected idiopathic interstitial pneumonia patients were randomly divided into jianzhi-liquid group (A group of 30 cases), jianzhi-liquid add glucocorticoids group (group B 30 cases), glucocorticoids group (group C 30 cases) three groups, A group of using jianzhi-liquid treatment, group B using jianzhi-liquid add glucocorticoids treatment, group C for medicine by glucocorticoids treatment, 12 weeks after treatment, patients were observed the clinical, radiological and physiological indexes change, and the change of the expressions of TGF-β1,TNF-α of serum. Experimental study establish the rat pulmonary fibrosis model, to observe the influence of jianzhi-liquid to the expression of TGF-β1, TNF-α of rat lung tissue. Result: Clinical score (C):the clinical score of three groups are significantly lower than before (P 0.05), group A and group B both does not have obvious difference (P 0.05), these are better than C group (P 0.05); Imaging score (R):three groups of patients are no significant of imaging scores improve; Physiological score (P) : the physiological score of three groups are significantly lower than before (P 0.05), three groups are between was significant difference compared, group B score is the most obvious poorer; group A t