散瘀化痰综合脏调理乳腺增生病辨证论治优化方案的研究.pdf

较对照组低，较治疗前积分减少更明显，与安慰剂比较有统计学差异 （P＜0.05）。（8） 试验组中出现 4 例 2 例次不 良事件，发生率为 1.66%；安慰剂组中出现 2 例 0 例次不 良事件，发生率为 1.66%，组间比较无统计学差异。（9）基层推广临床结果：对乳房 疼痛总有效率 72.86%，肿块总有效率 54.29%，主证总有效率 74.29%，中医证候总有 效率 74.29%，疾病总疗效显愈率 21.43%、总有效率 75.71%。 结论：本研究最终形成了规范、易行、便于推广的散瘀化痰为核心、综合脏腑调 理乳腺增生病辨证论治临床优化方案；经临床验证能减轻乳房疼痛，缓解乳房肿块及 改善全身症状及超声评价，疗效优于安慰剂，药效持久，对不同兼证作用均衡，且无 明显毒副作用；经基层医院临床推广，进一步验证了其有效性、安全性、基层医院的 适宜性与可操作性。 关键词 乳腺增生病；散瘀化痰；调理脏腑；开郁散结颗粒 The research on optim ized solution of treating the H M G by the m ethod of reducing phlegm and Scattering stasis as the core and synthetically conditioning function of organs Speciality：Surgery of Traditional Chinese M edicine Tutor: Professor Song A i-li A uthor: Guan X ing A bstract O bjective: O ptim ized solution of treating the H M G by the m ethod of reducing phlegm and Scattering stasis as the core and synthetically conditioning function of organs. Prove the effection,reliable,secure,and the feasibility of the solution scientifically,to form a standardized,easy,broad consensus diagnosis and treatm ent program due to H GM .M ethods: First,researched literature and evaluate the quality of clinical trials of treating H M G by TCM .then m ine the law of TCM and drug in treating H M G.and sum ed up our ow n clinical experience,then proposed our treatm ent program of H M G .Second,after several rounds of discussion by experts,the optim ized program form atted gradually.third, dem onstrate the effectiveness and security of the solution and K aiyu Sanjie Particles by the m ethod of m ultiple centers,random ,double-blind,parallel control.The syudy w as carried out in 7research center at the sam e tim e.Take 8w eeks as a treatm ent,then tell the patient to visit us at the tim e of 8w eeks after treating,the m ain outcom e m easure include the pain ,the lum ps,the system ic sym ptom s and the ultrasongraphic.A nd use the evaluation of qual