三黄固本胶囊治阴虚内热型SLE的疗效评价及对血清IL-8、IL-10的影响.pdfVIP

中 文 摘 要 目的：选用四川省名老中医特色方剂——三黄固本汤制作为胶囊，选取代表疾 病——系统性红斑狼疮，用传统与现代科学手段相结合，可望证实益气养阴解毒 法对于人体免疫系统的影响，为系统性红斑狼疮的治疗寻找新的途径。 方法：选取系统性红斑狼疮患者45例，随机分为治疗组30例，对照组15例， 分别采用中药三黄固本胶囊加激素与单纯使用激素者对比治疗，观察治疗组及对 照组治疗前后临床疗效，血清白介素－8（IL－8）、血清白介素－10（IL-10）的 水平及不良反应。 结果：治疗组和对照组临床疗效比较，总有效率分别为90.00％、66.67％，对 比有显著差别（P0.05）；治疗组和对照组中医临床症候比较，总有效率分别为 90.00％、73.33％，对比有显著差别（P0.05）；治疗前后治疗组、对照组血清 IL-8及 IL-10水平明显下降（P0.05），但治疗组下降更加明显（P0.05），有 统计学意义。两组不良反应对比，对照组不良反应明显多于治疗组（P0.01）， 有统计学意义。 结论：中药三黄固本胶囊配合激素治疗系统性红斑狼疮临床疗效确切，可降低 血清IL-8及IL-10水平，优于单纯激素治疗组，副作用少，值得临床进一步研 究并推广。 关键词：三黄固本胶囊 系统性红斑狼疮 益气养阴解毒 白介素 ABSTRACT Objective: We choose San Huang Gu Ben Tang that is the characteristic formula of a famous veteran doctor of TCM in Sichuan province, and make it into capsules. Also choose the typical disease— — Systemic Lupus Erythematosus (SLE) and use the combination of traditional method with modernistic scientific method, in order to confirm that tonifying qi , nourishing yin and clearing toxins has something to do with the immune system of human body. We want to find a new way to treat SLE. Methods : In this study, 45 SLE patients are at random divided into the therapeutic group(30cases, treated by Sanhuangguben capsule and glucocorticoid) and the control group (15cases, treated by glucocorticoid ). We compare and observe the clinical therapeutic effect, the level of IL-8 and IL- 10 in blood serum, the adverse reaction. Results: Comparing with the control group ’s clinical therapeutic effect, the total effective rate (90.00% of the therapeutic group is higher than 66.67% of the control group) is significantly different (P0.05). Comparing with the control group ’s TCM clinical symptom, the total effective rate (90.00% of the therapeutic group is higher than 73.33% of the