动脉炎症与CRP PPT课件.pptVIP

34062 Atherothrombosis v21 Inflammation and CRP Inflammatory Pathways in Atherogenesis Atherosclerosis: An Inflammatory Disorder Inflammation, Plaque Stability, and the Risk of Cardiovascular Events Evidence suggests that in ACS elevated inflammatory markers—in particular, CRP—predict the future risk of cardiovascular events Factors such as laminar arterial shear stress, oxidized LDL, free radicals, and infectious organisms can trigger the release of pro-inflammatory cytokines (eg, IL-1, TNF-?, IL-6) Inflammatory cytokines influence the stability and degradation of the fibrous cap, leading to plaque rupture and subsequent thrombosis hs-CRP and Risk of Future MI in Apparently Healthy Men Relative Risk of Cardiovascular Events According to Several Biochemical Markers Novel Risk Factors as Predictors of PAD CRP, the Metabolic Syndrome, and Future CV Events (N=14,719) Risk Factors for Future Cardiovascular Events: Women’s Health Study Markers of Inflammation in the Prediction of Cardiovascular Disease in Women hs-CRP, Aspirin, and Risks of Future Myocardial Infarction Inflammation, Statin Therapy, and Relative Risk of Recurrent Coronary Events Long-term Effect of Pravastatin on hs-CRP: Placebo and Pravastatin Groups CRP as a Method to Target Statin Therapy in Primary Prevention: AFCAPS/TexCAPS CRP, Metabolic Syndrome, and Future CV Events (N=14,719) Metabolic Syndrome and CRP Levels CRP Levels and Event-Free Survival Clinical Application of hs-CRP for Cardiovascular Risk Prediction Clopidogrel Reduces ADP-Induced Expression of Platelet-Derived CD40L Inflammation in Unstable Angina CRP and Outcome by Quartile inStented Patients Primary Pro-Inflammatory Cytokines (eg, IL-1, TNF-a) IL-6 “Messenger” Cytokine ICAM-1 Selectins, HSPs, etc. Liver Endothelium and other cells CRP SAA Adapted from Libby P et al. Circulation. 1999;100:1148–1150. Circulation Pro-inflammatory Risk Factors VSMCmigration Foam-cellformation Adherence andaggregation of platelets Adherence and