HDL和LDL风险评估与治疗PPT课件.pptVIP

The Pyramid of Recent TrialsRelative Size of the Various Segments of the Population Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) (1998) Evaluated the effects of lovastatin on first acute major coronary event in 6605 men and women without any coronary or vascular disease and with TC 180-254 mg/dl HDL-C ?45 mg/dl in men and ?47 mg/dl in women LDL-C 130-190 mg/dl, or LDL-C 125-129 mg/dl with TC/HDL-C ratio 6 Randomized to lovastatin 20 mg vs. placebo with titration to 40 mg with goal of LDL-C ?110 mg/dl Mean follow-up 5 years AFCAPS/TexCAPS Results AFCAPS/TexCAPS